ABSTRACT
The novel coronavirus disease - COVID-19 is a historic catastrophe that has caused many devastating impacts on human life and wellness. Researchers in academia and industry strive to understand the causes of this pandemic disease and find new therapeutics combating it. Consequently, the number of COVID-19 related publications increases rapidly, and it is too difficult for medical researchers and practitioners to keep up with the latest research and development. Literature filtering and categorization, and knowledge discovery can use text mining as a powerful tool. In this paper, we propose a text mining method to explore the categories of COVID-19 related themes and identify the standard methodologies that have been used. We discuss the potential limitations of this preliminary study and present future perspectives related to COVID-19 research. This paper provides an quantitative and qualitative mixed analysis example of using some research papers by data mining method to dig out several hidden information and set up a foundation for data scientists to develop more effective algorithms to deal with COVID-19 related problems.
ABSTRACT
Although striking effects of vaccination strategy against COVID-19 world-wide, a long-term influence by sequential viral mRNA injections are unknown. We analysed biological alterations by total RNA sequencing in Pfizer-BioNTech vaccinated normal healthy volunteers and cancer patients, with or without adjuvant Huaier therapy. A significant destruction in ribosomal RNA structures was identified, enhanced by serial shots. Unlike the destruction caused by chemotherapy with platinum (II) complex, progressive destruction in 18S ribosome was identified even at 6 months after vaccination. The influence resulted in massive inhibition of translation and transcription, significantly in intra/inter neural signaling transfer and in lipid metabolism, related to ageing process. Huaier compensated these dysfunctions by miRNA-mediated transcriptional control, by typical activation in PI3K/AKT signaling pathway. Gene Ontology analysis revealed spontaneous virion production in number even after 3 months of the first vaccination. Present study indicated that the adjuvant therapy like Huaier compensates accelerated ageing process by mRNA vaccination.